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Beilstein J. Org. Chem. 2013, 9, 1551–1558, doi:10.3762/bjoc.9.176
Graphical Abstract
Figure 1: The 2-methyl-4(1H)-quinolone compounds: aurachins and endochin.
Scheme 1: Synthesis of aurachin D (4) and geranyl (9), prenyl (10) and methyl (11) analogues.
Scheme 2: Strategy toward the heterocyclic core of aurachin H.
Figure 2: (A) Loss of mitochondrial membrane potential in human U-2 OS osteosarcoma cells that were treated w...